Optogenetic control of the enteric nervous system and gastrointestinal transit
نویسندگان
چکیده
منابع مشابه
Platinum-based chemotherapy: gastrointestinal immunomodulation and enteric nervous system toxicity.
The efficacy of chemotherapeutic treatment of colorectal cancer is challenged by severe gastrointestinal side effects, which include nausea, vomiting, constipation, and diarrhea. These symptoms can persist long after the treatment has been ceased. An emerging concept is the ability of platinum-based drugs to stimulate immunity, which is in contrast to conventional chemotherapeutic agents that a...
متن کاملThe enteric nervous system.
T HE enteric nervous system is a collection of neu-rons in the gastrointestinal tract 1 that constitutes the " brain of the gut " and can function independently of the central nervous system. 2 This system controls the motility, 3,4 exocrine and endocrine secretions, 5 and microcirculation 6 of the gastrointestinal tract; it is also involved in regulating immune and inflammatory processes. 7 In...
متن کاملThe human enteric nervous system.
Decades of work in animal models have demonstrated that the enteric nervous system (ENS) plays a key role in controlling gut functions. Recent advances made it possible to extend such studies to the ENS of man in health and even in disease. Such studies have already provided new insights into the pathophysiology of inflammatory and possibly functional bowel diseases. Studies on human ENS reveal...
متن کاملMigration of neural crest-derived enteric nervous system precursor cells to and within the gastrointestinal tract.
The enteric nervous system, the intrinsic innervation of the gastrointestinal tract, consists of large numbers of phenotypically diverse neurons and glial cells, arranged in complex interconnecting plexuses situated between the smooth muscle layers of the gut wall. Recently, the enteric nervous system has attracted much attention from developmental biologists whose efforts have focused on analy...
متن کاملCutting-edge technology. III. Imaging and the gastrointestinal tract: mapping the human enteric nervous system.
Monitoring membrane potentials by multisite optical recording techniques using voltage-sensitive dyes is ideal for direct analysis of network signaling. We applied this technology to monitor fast and slow excitability changes in the enteric nervous system and in hundreds of neurons simultaneously at cellular and subcellular resolution. This imaging technique presents a powerful tool to study ac...
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ژورنال
عنوان ژورنال: Expert Review of Gastroenterology & Hepatology
سال: 2019
ISSN: 1747-4124,1747-4132
DOI: 10.1080/17474124.2019.1581061